Gastrointestinal and Immune Systems in Autoimmunity
Master gut immunology, autoimmunity, and neurochemical case management through advanced clinical reasoning
Decode the gut-immune-brain axis and manage autoimmunity, dysbiosis, and neuroinflammation with a rigorous clinical framework.
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Course Description
Complex patients with relapsing symptoms, treatment-resistant presentations, and overlapping autoimmune patterns demand more than protocol-based care. The missing variable is often a failure to identify and address the metabolic and immunological roadblocks that prevent neurological rehabilitation from holding.
This module gives you a comprehensive, research-grounded command of gut immunology, intestinal barrier physiology, microbiota-brain signaling, autoimmune mechanisms, and the clinical tools to act on all of it. You will develop the clinical reasoning to recognize immune-driven patterns in blood chemistry, interpret WBC differentials and inflammatory markers with precision, and build targeted intervention strategies around diet, supplementation, and lab-guided decision-making. Real patient cases are woven throughout, showing how these principles translate into outcomes.
What you’ll learn:
- Interpret WBC differentials to identify immune activation, infection, and autoimmune patterns
- Apply the gut-immune-brain axis to explain and address treatment-resistant cases
- Identify autoimmune mechanisms including molecular mimicry and oral tolerance failure
- Use Vitamin D, CRP, and functional lab ranges to guide immune-targeted interventions
- Build case management plans using the Four Neurochemical Priorities framework
More About This Course
Clinical neurochemistry and functional medicine practitioners working with neurologically complex patients increasingly encounter a consistent pattern: neurological rehabilitation stalls, symptoms relapse, and standard workups come back unremarkable. The emerging body of evidence in gut immunology, microbiota-gut-brain axis research, and autoimmune neurology makes clear that metabolic and immunological barriers are often the rate-limiting factor in clinical outcomes. This module addresses that gap directly.
Module 4 of the Clinical Neurochemistry and Nutrition series builds on foundational neurochemical principles to deliver a clinically actionable framework for evaluating and managing the gut-immune-brain interface. Core topics include the innate and adaptive immune system, intestinal barrier physiology and tight junction regulation, the microbiota-gut-brain-immune axis, autoimmunity mechanisms including molecular mimicry and oral tolerance failure, white blood cell differential interpretation, CRP and Vitamin D as clinical markers, and the neurochemical priorities framework that guides case sequencing. Functional lab interpretation, including Cyrex Array 5 antibody panels, blood chemistry optimization, and HPA axis assessment, is integrated throughout.
This course is designed for licensed healthcare clinicians including chiropractors, chiropractic neurologists, functional medicine practitioners, naturopathic physicians, and other advanced clinicians who already possess a working knowledge of neurophysiology and are ready to integrate immunological and nutritional case management into their clinical decision-making. It is particularly valuable for practitioners who see patients with autoimmune diagnoses, treatment-resistant neurological presentations, or complex multi-system complaints that have not responded to conventional or standard functional approaches.
Dr. David Clark, DC, brings a rare combination of credentials to this content. A Fellow of the American College of Functional Neurology, Fellow of the American Board of Brain Injury and Rehabilitation, Diplomate of the American Chiropractic Neurology Board, Diplomate of the College of Clinical Nutrition, and Vestibular Rehabilitation Specialist, Dr. Clark draws on decades of clinical experience and an exhaustive reference library spanning neurochemistry, immunology, gastroenterology, and functional medicine. His teaching is distinguished by case-driven rigor, clinical honesty, and a commitment to reasoning over protocol.
Components
Educational Syllabus
- How to Work Up a Patient with Metabolic Complexity
- Develop a systematic intake process that extracts clinically actionable signals from history, symptoms, diet, and prior labs. Learn how to identify metabolic roadblocks before initiating receptor-based rehabilitation so that your neurological work has the substrate it needs to hold.
- Core Clinical Principles That Drive Superior Outcomes
- Master the reasoning principles that separate reactive from strategic clinical thinking. The Many Paths Principle, Testing Principle, 30-Day Rule, Ex Juvantibus Method, and Metabolic Capacity Rule are applied directly to patient decision-making throughout this module.
- HPA Axis and Adrenal Function Decoded
- Gain a clinically precise understanding of cortisol, DHEA, and ACTH dynamics, including the distinction between gland dysfunction and command dysfunction. Learn how HPA dysregulation drives immune dysfunction, dysglycemia, and treatment fatigue in your most challenging patients.
- Assessing and Treating HPA Axis Dysfunction
- Move from theory to action with evidence-based lifestyle, dietary, and adaptogenic intervention strategies for HPA axis dysfunction. Understand when adaptogens are indicated, which formulas to use, and how to structure the treatment timeline around objectively measurable outcomes.
- Glucose Dysregulation as a Neurochemical Barrier
- Distinguish reactive hypoglycemia, hypoglucocytosis, and insulin resistance by pattern recognition and functional lab interpretation. Learn targeted nutritional and supplemental strategies that restore glycemic stability and remove one of the most common barriers to neurological progress.
- The Immune System Architecture Every Clinician Must Know
- Build a working model of innate and adaptive immunity including barriers, NK cells, neutrophils, dendritic cells, T and B lymphocytes, cytokines, and immunoglobulin isotypes. This foundation makes every downstream immunological concept in the course clinically navigable.
- Autoimmunity Mechanisms and Clinical Recognition
- Understand how oral tolerance failure, molecular mimicry, intestinal hyperpermeability, and genetic susceptibility converge to produce autoimmune disease. Learn the three stages of autoimmune development and how to recognize subclinical autoimmunity before it reaches the clinical threshold.
- WBC Differential Mastery for Immune Pattern Recognition
- Develop fluency interpreting WBC count, neutrophil, lymphocyte, monocyte, and eosinophil patterns in ways that reveal bacterial infection, viral patterns, chronic immune activation, and autoimmune suppression. Learn the combinations that indicate mycotoxin exposure, Epstein-Barr, and bone marrow suppression.
- CRP, Vitamin D, and Key Inflammatory Markers
- Understand how to use high-sensitivity CRP and Vitamin D as dynamic clinical tools rather than static reference values. Learn functional target ranges for autoimmune versus non-autoimmune patients, preferred administration routes, and dosing strategies tied to baseline levels and 60-day retesting.
- The Microbiota-Gut-Brain-Immune Axis
- Explore the bidirectional communication network linking gut microbiota, the enteric nervous system, the immune system, and the central nervous system. Understand how dysbiosis drives neuroinflammation, behavioral changes, and immune dysregulation, and how short-chain fatty acids modulate the entire axis.
- Intestinal Barrier Physiology and Hyperpermeability
- Gain a mechanistic understanding of tight junction regulation, zonulin signaling, and the factors that breach or restore gut barrier integrity. Learn how intestinal hyperpermeability creates the preconditions for autoimmunity and neuroinflammation and what nutritional interventions most effectively restore barrier function.
- Food Antigens, Molecular Mimicry, and Autoimmune Triggers
- Understand how specific food proteins including wheat, milk, corn, eggs, and pork share structural homology with human tissues and how this drives tissue-specific antibody production. Learn which cross-reactions are clinically relevant, how to evaluate food sensitivity testing evidence critically, and how to apply elimination strategies strategically.
- Testing and Treating Clinically Significant Autoimmunity
- Learn how to use ANA panels, Cyrex Array 5 tissue antibody testing, and the Immune System Challenge to identify cytokine polarity and guide immune-targeted intervention. Work through the surgical strike method for building individualized treatment plans across diet, barrier repair, immune regulation, and supplementation.
- Complex Case Studies in Neurochemical and Immune Management
- Apply every concept from the module to real longitudinal cases including autoimmune arthritis, Type 1 diabetes with neurological sequelae, Hashimoto's with iron deficiency, celiac disease with psychiatric comorbidities, and treatment-resistant vestibular and cognitive presentations tracked across multiple follow-up visits.
Venue, Hotels & Schedule
Also includes


Gastrointestinal and Immune Systems in Autoimmunity
Decode the gut-immune-brain axis and manage autoimmunity, dysbiosis, and neuroinflammation with a rigorous clinical framework.
$
$
(
$
The Carrick Institute team is ready to assist with enrollment, CE approval, or program planning. Email visit our CE Portal or Contact Us directly.
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