Course Description
Complex patients rarely fit a single-organ explanation. When the hypothalamus, pituitary, adrenal cortex, thyroid, and pancreas interact with immune function and brain chemistry, the clinician without an integrated neuroendocrine framework is left guessing. That gap costs patients.
This 15-credit course with Dr. David Clark gives you the integrated framework to stop guessing. You will understand how the HPA, HPT, and HPG axes regulate fuel, mood, metabolism, and immune tolerance. You will learn to recognize cortisol dysregulation, thyroid conversion patterns, and glucose handling failures at the level of clinical presentation and laboratory interpretation. From Cushing's syndrome to Hashimoto's, from adrenal insufficiency to diabetic neuropathy, you gain the clinical map that connects neuroendocrine dysfunction to the patients in your practice. This is not pathophysiology for its own sake. It is the foundation of more precise, more effective, and more confident clinical care.
What you’ll learn:
- Interpret the HPA, HPT, and HPG axes and apply them to complex patient presentations
- Recognize clinical presentations of cortisol excess, deficiency, and HPA dysregulation
- Analyze thyroid lab panels including conversion patterns, antibodies, and TSH context
- Identify glucose dysregulation patterns and their impact on neurological function
- Distinguish autoimmune endocrine conditions and determine appropriate clinical action
More About This Course
The neuroendocrine system is not a collection of isolated glands. It is a deeply integrated network in which the brain regulates hormonal output, hormonal output regulates brain function, and disruption anywhere in that loop creates consequences that ripple across every system a clinician touches. For licensed healthcare providers pursuing advanced functional medicine training, understanding neurochemistry and the endocrine system at a systems level is no longer optional. The patients presenting with fatigue, dysglycemia, mood instability, weight dysregulation, infertility, or treatment-resistant pain often carry an unresolved neuroendocrine driver that conventional workups never identified. This course is built to close that gap with precision.
CNS17 Neurochemistry and the Endocrine System is a 15-credit post-graduate course presented by Dr. David Clark, DC, DACNB, FACFN, FABVR, FABBIR, FABNN. The course gives clinicians a working command of the hypothalamic-pituitary axis and its three major regulatory arms: the HPA axis governing cortisol and adrenal function, the HPT axis governing thyroid hormone synthesis and conversion, and the HPG axis governing gonadal hormone regulation. Beyond axis mechanics, the course addresses the blood-brain barrier and its clinical vulnerabilities, the role of the cerebellum in hypothalamic regulation, and how neuroendocrine dysfunction manifests in the conditions clinicians encounter regularly, including Hashimoto's thyroiditis, Graves disease, Cushing's syndrome, adrenal insufficiency, PCOS, type 1 and type 2 diabetes, and diabetic neuropathy. Laboratory interpretation is integrated throughout, including thyroid panel analysis, cortisol assessment, glucose and HbA1c interpretation, and antibody panels for autoimmune endocrine conditions. Clinicians also gain a framework for understanding when to test, when to refer, and how a diagnosed neuroendocrine condition changes the clinical approach within their existing scope of care.
This course is designed for chiropractors, chiropractic neurologists, naturopathic physicians, and other licensed clinicians pursuing a more integrated understanding of brain-body regulation. Whether you are preparing for board certification, refining your clinical reasoning with complex cases, or building a functional medicine practice approach, this course provides a scientifically grounded, clinically applicable framework that immediately informs how you evaluate and manage the patients in your care.
Dr. David Clark is a board-certified chiropractic neurologist and diplomat of the American Chiropractic Neurology Board. He holds advanced certifications in functional neurology, functional medicine, and neuroimmunology and brings an evidence-based approach to topics that are often oversimplified or misrepresented in clinical education. His teaching draws on primary peer-reviewed literature and major reference texts across endocrinology, neurochemistry, immunology, and clinical physiology. Clinicians who have trained with Dr. Clark consistently report a fundamental shift in how they read labs, interpret symptoms, and apply neuroendocrine principles to their clinical decision-making.
Components
Educational Syllabus
- The Brain as Endocrine Command Center
- The hypothalamus is the brain's primary neuroendocrine transducer, converting neural input into hormonal output via the portal system and direct neurohypophyseal release. This architecture underlies every clinical axis in this course.
- The Blood-Brain Barrier and Where It Breaks Down
- The BBB regulates ionic gradients, nutrient exchange, and toxin exclusion. Clinicians need to know what disrupts it, from cytokines and trauma to amyloid beta, and why circumventricular organs are where brain-body chemical signaling occurs.
- HPA Axis Tone and the Fuel Crisis in Your Patient's Brain
- The brain cannot store glucose. The HPA axis keeps it fueled between meals. Low HPA tone explains the patient who cannot skip meals, crashes in the afternoon, and wakes at 3am. Learn to recognize and address this pattern.
- Cortisol Excess and Deficiency Across the Clinical Spectrum
- From Cushing's syndrome to primary, secondary, and tertiary adrenal insufficiency, clinicians gain a working map of cortisol pathophysiology, laboratory interpretation, and the clinical signs that warrant referral or immediate action.
- Thyroid Axis Mastery From TSH to Dysconversion Patterns
- Go beyond TSH and Free T4. Master the full thyroid panel including T3, Reverse T3, deiodinase conversion, binding proteins, and antibody interpretation to accurately classify hypothyroid, hyperthyroid, and conversion failure patterns.
- Hashimoto's and Graves Disease in Clinical Practice
- Distinguish Hashimoto's from Graves disease using antibody profiles, lab patterns, and clinical signs. Understand how autoimmune thyroid disease fluctuates, when it causes hypothyroidism versus thyrotoxicosis, and what that means clinically.
- The Gonadal Axis From PCOS to Hypogonadism
- Map the HPG axis through menstrual cycle regulation, amenorrhea, PCOS, ovarian failure, Klinefelter syndrome, and stress-induced hypogonadism. Learn how gonadal axis disruption presents clinically and how it affects your patients' overall function.
- Pituitary Adenomas and the Consequences of Mass Effect
- Prolactinomas, GH-secreting tumors, ACTH-producing adenomas, and non-functioning chromophobe tumors each produce distinct syndromes. Recognize bitemporal hemianopia, acromegaly signs, hyperprolactinemia, and the pituitary tumor symptom cluster.
- Glucose Dysregulation and Its Consequences for the Brain
- From prediabetes to overt type 1 and type 2 diabetes, explore how dysglycemia drives dementia risk, hippocampal volume loss, diabetic neuropathy, retinopathy, and autonomic dysfunction. Learn to test, interpret, and act on glucose markers clinically.
- Integrating Neuroendocrine Findings Into Clinical Action
- Synthesize the full course into a working clinical framework. Know when to test, when to refer, and how a neuroendocrine diagnosis changes your approach. Apply HPA tone stabilization and glucose strategies to your current patient population.
Venue, Hotels & Schedule
Also includes


Neurochemistry & The Endocrine System
Decode the neuroendocrine system and elevate your clinical reasoning across HPA, thyroid, gonadal, and metabolic axes in 15 CE credits.
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