A Small Molecular Compound to Increase Endogenous Neural Stem Cells for Neurodegenerative Therapies
How a small molecule compound may restore neurogenesis and reverse cognitive decline in aging and Alzheimer's disease
Discover how activating your patients' own neural stem cells may reverse cognitive decline without surgery or cell transplantation.
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Course Description
Neurodegeneration is outpacing every treatment category in modern medicine. Alzheimer's disease alone will affect over 150 million people by 2050, and existing therapies address symptoms while the underlying biology continues to deteriorate. The clinical gap is not in effort. It is in mechanism.
This course presents a compelling frontier in regenerative neuroscience: a small molecule compound capable of crossing the blood-brain barrier and stimulating endogenous neural stem cell proliferation. You will explore the science behind APC-100, a dual-action compound combining KS217 and Fenselin, and how this approach has demonstrated the ability to restore neurogenesis, reduce amyloid precursor protein expression, and reverse spatial memory deficits in validated animal models. This is disease-modifying science with prevention implications, and it is advancing toward human trials.
What you’ll learn:
- Explain the role of endogenous neural stem cells in age-related cognitive decline
- Identify how APC-100 activates neurogenesis without surgery or transplantation
- Describe how amyloid precursor protein suppresses neural stem cell differentiation
- Apply the dual-mechanism model to Alzheimer's and Parkinson's disease contexts
- Evaluate the translational readiness of small molecule neurogenesis therapies
More About This Course
Regenerative neuroscience is redefining what is possible in the treatment of neurodegenerative disease. For decades, Alzheimer's disease, Parkinson's disease, and age-related cognitive decline have resisted pharmacological intervention because available treatments address downstream symptoms rather than the upstream biology of neuronal loss. The emergence of small molecule neurogenesis activators, endogenous neural stem cell stimulation, and blood-brain barrier-permeable compounds represents a fundamental shift in therapeutic strategy. This course positions clinicians at that frontier.
Presented by Dr. Kiminobu Sugaya, PhD, Professor and Head of Neuroscience at the University of Central Florida College of Medicine, this one-hour continuing education course explores the science behind APC-100, a compound that combines KS217, a neural stem cell proliferation activator, and Fenselin, an amyloid precursor protein expression reducer. Together, this dual-mechanism approach has demonstrated up to a 600 percent increase in endogenous neural stem cell activity and full restoration of spatial memory in five-gene familial Alzheimer's disease transgenic mouse models. No surgery. No cell preparation. Oral administration only.
This course is designed for licensed healthcare clinicians working at the intersection of neurology, functional medicine, rehabilitation, and human performance who want to understand where regenerative science is heading and why the mechanisms driving it matter for clinical decision-making today. Whether you manage patients with early cognitive decline, advise on neuroprotective strategies, or simply want to understand the science your field is moving toward, this course delivers substantive, research-grounded insight from a researcher who has spent decades building it.
Dr. Sugaya's laboratory at UCF has pioneered techniques for reprogramming mesenchymal stem cells toward neural lineages, developing salivary biomarkers for brain staging, and advancing translational research funded by the NIH, the Alzheimer's Association, and the Florida Department of Health. His work challenges the amyloid hypothesis not from the margins but from a position of published, peer-reviewed evidence spanning more than two decades. This course reflects that depth.
Components
Educational Syllabus
- The Aging Brain and the Stem Cell Deficit
- Aging is the single greatest risk factor for Alzheimer's disease. This topic establishes why endogenous neural stem cell loss drives cognitive decline and why restoring that population is a more precise target than symptomatic pharmacology.
- Neurogenesis From Within: The Small Molecule Approach
- KS217 crosses the blood-brain barrier and stimulates neural stem cell proliferation by up to 600 percent in aged memory-impaired models. Clinicians gain a mechanistic understanding of how oral compounds can activate the brain's own regenerative capacity.
- How APP Hijacks Stem Cell Differentiation
- Elevated amyloid precursor protein redirects neural stem cells toward astrocyte production, halting neurogenesis. This topic explains why increasing stem cells alone is insufficient and how Fenselin restores the neural differentiation pathway.
- APC-100 in Action: Dual Therapy and Clinical Horizons
- Combining KS217 and Fenselin as APC-100 restored normal spatial memory in five-gene familial Alzheimer's transgenic models. Clinicians explore disease-modifying potential, prevention applications, and the translational pathway toward human trials.
Venue, Hotels & Schedule
Also includes


A Small Molecular Compound to Increase Endogenous Neural Stem Cells for Neurodegenerative Therapies
Discover how activating your patients' own neural stem cells may reverse cognitive decline without surgery or cell transplantation.
$
$
(
$
The Carrick Institute team is ready to assist with enrollment, CE approval, or program planning. Email visit our CE Portal or Contact Us directly.
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